This investigation reveals antimicrobial effects of monoterpene indole alkaloids against Helicobacter pylori, suggesting potential for overcoming antibiotic resistance.
Key Points
Compounds from Tabernaemontana elegans showed significant antibacterial activity against H. pylori, highlighting their therapeutic potential.
Active monoterpene indole alkaloids displayed MIC values between 10 and 20 µM, indicating effective inhibition of bacterial growth.
Testing revealed specific alkaloids inhibited biofilm formation at sub-inhibitory concentrations, promoting their use in treatment strategies.
Cytotoxicity assessments indicated favorable safety profiles with CC50 values above MICs, supporting further development as alternative treatments.