Investigation reveals inconsistencies in meta-analyses about calcium supplementation's effect on preeclampsia risk in pregnant individuals, highlighting possible biases.
Key Points
Calcium supplementation appears to reduce the risk of preeclampsia, particularly among those with low calcium intake.
The meta-analysis showed a mean risk ratio of 0.45, suggesting significant benefits for specific populations.
Observational analysis reviews the influence of smaller trials on overall outcomes reported in previous studies.
Findings indicate that there may be biases in earlier studies, prompting updates to clinical guidelines on supplementation.