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January 1, 2025Advances in HematologyOpen Access

Real‐World Safety and Efficacy of Venetoclax in Chronic Lymphocytic Leukemia: A Single‐Center Comparative Analysis With Randomized Clinical Trials

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Authors

STSophie ThauCPChristian Bjørn PoulsenMLMorten Kranker Larsen

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Overview

Analysis compares efficacy and safety outcomes of venetoclax treatment in real-world CLL patients versus randomized clinical trials, suggesting equivalency in results.

Key Points

  • Patients treated with venetoclax for chronic lymphocytic leukemia show similar outcomes regardless of treatment setting.
  • Both treatment cohorts exhibited acceptable tolerability and safety profiles to venetoclax with no significant differences observed.
  • Observational analysis included 112 patients treated either in the standard practice or through randomized clinical trials.
  • Findings indicate that real-world CLL patients have comparable safety and efficacy profiles to those reported in established RCTs.

Cite This Study

Thau et al. (2025) studied this question.

synapsesocial.com/papers/68af3e42cf1dd9ea359eb267https://doi.org/10.1155/ah/3910332
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