Retinal Occlusive Vasculitis after Intravitreal Brolucizumab Injection for Wet Age-related Macular Degeneration

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Case report reveals retinal occlusive vasculitis post-injection of brolucizumab in a patient, suggesting enhanced monitoring for complications.

Retinal occlusive vasculitis developed after injection of brolucizumab, resulting in decreased visual acuity and central scotoma.
Fluorescein angiography showed retinal arterial filling defects, and inner retinal hyper-reflectivity was noted on optical coherence tomography.
Case involves a 73-year-old woman with wet age-related macular degeneration, with prior treatment ineffective after aflibercept injections.
Treatments included steroid drops and triamcinolone acetonide, leading to resolution of symptoms, highlighting the need for prompt interventions.

Kee et al. (2025) studied this question.

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Case report reveals retinal occlusive vasculitis post-injection of brolucizumab in a patient, suggesting enhanced monitoring for complications.