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August 15, 2025Open Access

Behavioural and Pharmacological Interventions for the Management of Pain Perceptions in Rheumatoid Arthritis: A systematic-review and meta-analysis

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Authors

CNCharlie Joseph NealeASAndrew Soundy

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Overview

Systematic review demonstrates that pharmacological interventions significantly reduce pain perceptions in RA patients, suggesting a preference for DMARDs and NSAIDs over other therapies.

Key Points

  • Pharmacological interventions showed a weighted mean difference of −11.20mm in pain perceptions, significantly reducing discomfort in RA patients.
  • Pharmacological and physical activity interventions both effectively reduced pain perceptions, highlighting their importance in treatment protocols.
  • A systematic review and meta-analysis evaluated trials over 25 years, demonstrating the efficacy of both DMARDs and NSAIDs in pain management.
  • Findings suggest DMARDs or NSAIDs may provide greater pain relief compared to non-pharmacological therapies such as yoga or aerobic training.

Cite This Study

Neale et al. (2025) studied this question.

synapsesocial.com/papers/68af3e3ccf1dd9ea359eadd3https://doi.org/10.1101/2025.08.14.25333667
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