Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025The Journal of Cardiovascular AgingOpen Access

Epigenetic and epitranscriptomic regulation of cardiac metabolism in aging and disease

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJianjun LiuMYMin YangBZBoda Zhou

Discussion

Loading...

Member takes

Overview

This review demonstrates epigenetic and epitranscriptomic factors impact cardiac metabolism in aging, highlighting potential therapeutic strategies.

Key Points

  • Metabolic inflexibility arises from dysregulated epigenetic pathways, contributing to heart failure and ischemia-reperfusion injury.
  • Key finding: Age-related impairments in SIRT1/NAD+ activity disrupt fatty acid oxidation and increase glycolytic dependency.
  • This review evaluates mechanisms like DNA methylation and RNA modifications in cardiac metabolism across aging and disease.
  • Emerging therapies like BET inhibitors show potential in restoring metabolic flexibility through epitranscriptomic pathways.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68af3e34cf1dd9ea359eaa44https://doi.org/10.20517/jca.2025.06
View Full Paper
Ask AI
Bookmark
Share