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August 18, 2025Diabetes Obesity and Metabolism

Comparison of subcutaneous, visceral, liver and muscle fat depots in relation to prevalent and incident diabetes

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Authors

DWDanyang WangJMJedidiah I MortonDMDianna J. Magliano

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Overview

Observational analysis revealed strong links between fat depots and diabetes in 44,857 UK Biobank participants, suggesting interventions targeting visceral fat may be critical.

Key Points

  • Higher levels of visceral fat significantly increase diabetes risk, with an HR of 2.44 per standard deviation increase.
  • Analysis showed that subcutaneous and liver fat were also associated with diabetes, but to a lesser extent than visceral fat.
  • Logistic and Cox regression analyses were used to estimate associations with prevalent and incident diabetes, respectively.
  • Findings highlight the need for targeting visceral fat in diabetes prevention strategies, especially for high-risk individuals.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af35e9cf1dd9ea359ea3f1https://doi.org/10.1111/dom.70021
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age2015 · 13,925 citations