Experimental analysis shows avenanthramide-C improves cognitive function in obese mice with Alzheimer's, indicating neuroinflammation roles.
Key Points
Avenanthramide-C effectively reduced Aβ deposition and enhanced synaptic function in obese 5×FAD mice, improving cognitive performance.
Key evidence shows improved spatial and recognition memory outcomes, alongside restored synaptic plasticity and reduced neuroinflammation.
The study utilized two-month-old male 5×FAD mice on a high-fat diet, treated with avenanthramide-C, assessing various cognitive and synaptic parameters.
These findings suggest avenanthramide-C may serve as a therapeutic strategy against obesity-related Alzheimer’s disease pathologies.