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August 19, 2025AntioxidantsOpen Access

Epigenetic Regulation in Ischemic Neuroprotection: The Dual Role of HDACs and HATs in Neuroinflammation and Recovery

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Authors

MLMalwina LisekNBNatalia BochenskaJTJulia Tomczak

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Overview

Observational analysis shows dual roles of hdacs and hats in neuroinflammation and neuroprotection, suggesting new therapeutic avenues.

Key Points

  • Selective hdac inhibitors may alleviate ischemic damage and support neuroprotection, with implications for recovery.
  • Histone acetyltransferases generally enhance cell survival and repair processes during ischemic events.
  • HDAC isoforms have been linked to microglial activation and neuronal apoptosis, indicating important regulatory roles.
  • Understanding epigenetic mechanisms could guide novel strategies that promote resilience against ischemic injuries.

Cite This Study

Lisek et al. (2025) studied this question.

synapsesocial.com/papers/68af35e3cf1dd9ea359ea009https://doi.org/10.3390/antiox14081015
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