January 1, 2025Open MedicineOpen Access

Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation

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Discussion

Experimental analysis revealed electroacupuncture reduces myocardial ischemia damage, suggesting FTO modulation influences m6A methylation.

Electroacupuncture treatment significantly reduced myocardial injury and improved cardiac function, as shown by preserved ejection fraction.
Myocardial infarct size decreased following electroacupuncture, highlighting its cardioprotective effects in ischemia-reperfusion scenarios.
Utilizing a murine model, the study showed electroacupuncture enhances FTO expression and reduces m6A methylation levels.
Findings suggest that decreased Med1 mRNA expression following treatment may lower cardiomyocyte apoptosis, indicating a protective mechanism.

Zou et al. (2025) studied this question.

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Experimental analysis revealed electroacupuncture reduces myocardial ischemia damage, suggesting FTO modulation influences m6A methylation.