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August 19, 2025Discover OncologyOpen Access

Identification of copper metabolism-related subtypes, the development of a prognosis model, and characterization of the immune landscape in colorectal cancer

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Authors

PGPeng GengLZLin ZhongNLNan Lai

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Overview

Analysis identifies distinct copper metabolism-related subtypes in CRC with varying overall survival outcomes, suggesting CMGs as predictive markers for immunotherapy.

Key Points

  • Patients classified into distinct copper metabolism-related subtypes showed significant differences in overall survival (OS), indicating a link to prognosis.
  • Cox regression analysis identified copper metabolism-related genes (CMGs) as critical markers, associated with variations in immune microenvironment characteristics.
  • Unsupervised clustering of patients based on CMGs revealed three subtypes, with subtype A linked to a poorer prognosis and higher expression of immune checkpoints.
  • A nomogram incorporating CMGs risk scores effectively predicted OS at multiple time points, providing a valuable tool for patient stratification in CRC.

Cite This Study

Geng et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9e40https://doi.org/10.1007/s12672-025-03183-x
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