August 19, 2025Translational PsychiatryOpen Access

Pharmacogenetic study of antipsychotic–induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study

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Genome-wide association study identifies SNPs linked to lipid changes in patients on antipsychotics, suggesting personalized treatment strategies.

Significant SNPs linked to lipid changes were identified in patients receiving second-generation antipsychotics.
The study analysed 19,316 prescription records and 3,917 to 7,596 metabolic measurements per outcome in 669 patients.
Genome-wide association study methodology revealed six significant genes after statistical corrections were applied.
Findings highlight the potential for personalized treatment strategies in schizophrenia patients to reduce metabolic risks.

Wong et al. (2025) studied this question.

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Genome-wide association study identifies SNPs linked to lipid changes in patients on antipsychotics, suggesting personalized treatment strategies.