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August 19, 2025Scientific ReportsOpen Access

Augmenting phage therapy using green nanotechnology for promising infection control, wound healing and devoiding phage resistance in MDR Pseudomonas aeruginosa

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Authors

AMAbishek ManiAMAarcha Shanmugha MaryCentral University of Tamil NaduNKNashath Kalangadan

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Implication

Combination therapy improves antibacterial efficiency in multidrug-resistant Pseudomonas aeruginosa, highlighting potential against antimicrobial resistance.

Key Points

  • Combination therapy with AgNPs and phages delayed phage resistance by 6-12 hours, enhancing effectiveness against MDR bacteria.
  • Antibacterial efficiency improved by approximately 40% for biofilm activity compared to using AgNPs alone.
  • Comprehensive evaluations showed excellent compatibility of AgNPs and phages over a 30-day period, maintaining phage titer.
  • Biocompatibility assays verified the safety of biosynthesized AgNPs, suggesting potential for wound healing in clinical settings.

Cite This Study

Mani et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9c04https://doi.org/10.1038/s41598-025-00449-w
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