Discovery of Pyrimidinedione Derivatives as Potential Herbicides: Design, Synthesis, and Evaluation of Herbicidal Activity

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Design and synthesis of pyrimidinedione compounds improved herbicidal activity in plants, indicating their potential as eco-friendly agents.

Most tested pyrimidinedione derivatives showed strong herbicidal activity against broadleaf weeds, achieving 100% efficacy in select trials.
Compound 6q displayed remarkable herbicidal activity at a low application rate of 9.375 g a.i./ha against specific weed species.
Molecular docking procedures revealed critical interactions of 6q with key amino acids, supporting its herbicidal mechanism.
Electrostatic potential analysis indicated that charge distribution directly correlates with herbicidal efficacy.

Pei et al. (2025) studied this question.

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Design and synthesis of pyrimidinedione compounds improved herbicidal activity in plants, indicating their potential as eco-friendly agents.