Evaluation of albendazole and mebendazole-loaded polymeric nanoparticles efficacy against larval stages of the Echinococcus granulosus parasite in vitro and in vivo
This analysis demonstrates improved efficacy of albendazole and mebendazole-loaded nanoparticles against hydatid cysts in infected mice, suggesting enhanced treatment options.
Key Points
Albendazole and mebendazole-loaded nanoparticles significantly reduced hydatid cyst size in infected mice, showing promising results.
The lethal concentration (LC50) for albendazole-loaded nanoparticles was 27.35 µg/ml, compared to 105.5 µg/ml for the drug alone; mebendazole-loaded nanoparticles also showed improved efficacy.
Assessment involved in vitro testing on protoscoleces and in vivo trials on mice infected with Echinococcus granulosus.
These findings support the potential for polymeric nanoparticles to enhance the treatment of echinococcosis, warranting further investigation.