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August 19, 2025Indian Journal of NeurosurgeryOpen Access

Classification of Glioblastoma Based on Immunohistochemical Expression of IDH-1, p53, and ATRX: A Study from a Tertiary Care Center in South India

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Authors

HTHiba ThankayathilGAGovindan AparnaSKSupriya Nilambur Kovilakam

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Overview

Descriptive cross-sectional study analyzes protein markers in 95 glioblastoma cases, suggesting implications for targeted therapies.

Key Points

  • Majority of glioblastoma cases revealed high p53 expression, indicating aggressive tumor characteristics and potential poor prognosis.
  • Out of 95 cases, 37.9% showed p53 overexpression while 46.3% exhibited loss of ATRX expression, reflecting possible biomarkers for classification.
  • The study utilized immunohistochemical testing on glioblastoma samples over five years at a tertiary care center, highlighting regional insights.
  • These findings suggest a link between IDH mutations, p53, and ATRX, which may facilitate developments in targeted therapies for glioblastoma.

Cite This Study

Thankayathil et al. (2025) studied this question.

synapsesocial.com/papers/68af35d5cf1dd9ea359e99c8https://doi.org/10.1055/s-0045-1811228
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