August 19, 2025Neurology

Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease

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Authors

SYS.F. Yim SPSeongbeom Park KLKok Hing Lim

Discussion

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Implication

Prospective cohort study finds MRI and plasma p-tau217 accurately predict Aβ positivity in early-stage Alzheimer disease, suggesting efficient risk stratification.

Key Points

The integrated workflow showed an overall accuracy of 94.2% in predicting Aβ PET positivity in early-stage Alzheimer disease.
Participants were effectively stratified into risk groups with positive predictive values reaching 97.6% in the high-risk category.
This diagnostic approach utilized MRI features and plasma p-tau217 to minimize unnecessary testing, enhancing efficiency.
Generalizability may be affected due to limited diversity and only modest improvements over existing models.

Cite This Study

Yim et al. (2025) studied this question.

synapsesocial.com/papers/68af35d5cf1dd9ea359e9852 https://doi.org/10.1212/wnl.0000000000213954

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Implication

Prospective cohort study finds MRI and plasma p-tau217 accurately predict Aβ positivity in early-stage Alzheimer disease, suggesting efficient risk stratification.