Observational study found kidney dysfunction predicts increased mortality and chronic kidney disease in adults with SCD, suggesting improved monitoring methods are needed.
Key Points
KDIGO-defined kidney dysfunction significantly predicts CKD progression and mortality risk in adults with sickle cell disease, enhancing patient monitoring.
Overall, 39.8% of adults with sickle cell disease were identified with KDIGO-defined chronic kidney disease, posing a serious health risk.
Incremental increases in urine albumin-to-creatinine ratio doubled the risk for kidney disease progression over a median follow-up time of 3.3 years.
Utilizing KDIGO criteria strengthens the predictive value for patient outcomes, indicating potential for improved intervention strategies and care plans.