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August 16, 2025Open Access

A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer

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Authors

PTPaola TieppoHSHussein ShehadeCMChiara Martinoli

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Overview

A2AR involvement impairs B cell function and maturation in the tumor microenvironment, indicating new therapeutic targets.

Key Points

  • Adenosine promotes immune suppression by inhibiting B cell maturation, impacting antitumor responses.
  • High levels of A2AR expression were found in plasma cells and other B cells within the tumor microenvironment.
  • In vitro activation of A2AR suppressed immunoglobulin production and B cell maturation, reversable by inupadenant.
  • These findings suggest A2AR antagonism could enhance B cell function in cancer immunotherapy.

Cite This Study

Tieppo et al. (2025) studied this question.

synapsesocial.com/papers/68af33efcf1dd9ea359e96f3https://doi.org/10.1101/2025.08.13.669666
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