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August 19, 2025Open Access

Inference of lineage hierarchies, growth and drug response mechanisms in cancer cell populations without tracking

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Authors

APAndrea PirasFGFederica GalvagnoLPLetizia Pizzini

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Overview

New method uncovers growth mechanisms and drug responses in cancer, suggesting lineage dynamics impact treatment outcomes.

Key Points

  • Our method accurately predicts growth mechanisms in cancer cell populations, improving treatment strategies.
  • Analysis demonstrated that phenotype transitions can be quantified solely through lineage counting, without tracking.
  • Experimental validation showcased the method's effectiveness in predicting drug response in various cancer cell populations.
  • Understanding lineage dynamics is crucial to rationally designing therapeutic approaches against drug resistance.

Cite This Study

Piras et al. (2025) studied this question.

synapsesocial.com/papers/68af33e9cf1dd9ea359e930fhttps://doi.org/10.1101/2025.08.14.669184
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