August 19, 2025CellsOpen Access

Nonsense-Mediated mRNA Decay: Mechanisms and Recent Implications in Cardiovascular Diseases

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This review reveals the implications of nonsense-mediated mRNA decay in cardiovascular disease, suggesting its therapeutic potential in treatment.

Dysregulation of nonsense-mediated mRNA decay contributes to cardiovascular diseases and other conditions, affecting protein synthesis.
Key components such as up-frameshift proteins and eukaryotic release factors are essential in regulating mRNA stability.
The review examines how targeting NMD could mitigate genetic mutations and improve treatment options for cardiovascular diseases.
Understanding NMD mechanisms may enhance personalized medicine approaches in treating conditions linked to gene regulation.

Hassan et al. (2025) studied this question.

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This review reveals the implications of nonsense-mediated mRNA decay in cardiovascular disease, suggesting its therapeutic potential in treatment.