August 19, 2025Advanced ScienceOpen Access

Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury

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Discussion

Mitochondrial transplantation enhances cardiac function and macrophage repair in myocardial infarction, suggesting a novel therapy.

Mitochondrial transplantation significantly improves the healing capabilities of macrophages after myocardial infarction.
In vivo results show enhanced cardiac function and reduced fibrosis following mitochondrial transplantation therapy.
The approach includes introducing healthy mitochondria into macrophages, promoting their transition to a reparative state.
These findings indicate that mitochondrial transplantation could serve as a promising treatment for myocardial injuries.

Zhang et al. (2025) studied this question.

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