August 19, 2025Scientific ReportsOpen Access

A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics

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Computational design shows strong immune responses in multi-epitope mRNA vaccine against rabies, indicating broad coverage.

The study proposes a novel mRNA vaccine against rabies virus, aiming for strong immune responses with only one construct.
Primary findings include high binding affinity to HLA alleles, achieving effective T-cell recognition with a 96% coverage.
Reverse vaccinology and bioinformatic tools guided the epitope selection process, focusing on nonhuman homologs for safety.
In silico simulations predict long-lasting immunity and require further experimental validation in systemic animal models.

Tombari et al. (2025) studied this question.

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