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August 18, 2025Frontiers in MedicineOpen Access

Elevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an increased propensity for perioperative cerebrovascular events

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Authors

KLKrzysztof LaudańskiMAMohamed A. AntarHGH. Gad

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Overview

Investigation shows elevated MCP-1 linked to inflammation in patients, suggesting implications for neurocognitive decline and adverse outcomes.

Key Points

  • Elevated MCP-1 levels persist for up to 3 months after cardiac surgery, indicating possible links to ongoing inflammation.
  • Serum MCP-1 levels at 24 hours, 7 days, and 3 months were compared to baseline levels in 71 cardiac surgery patients.
  • The study involved analyzing serum markers, including IL-6, neurodegeneration, and vascular inflammation post-surgery.
  • Elevated MCP-1 levels suggest a potential biomarker for adverse postoperative outcomes, calling for further exploration.

Cite This Study

Laudański et al. (2025) studied this question.

synapsesocial.com/papers/68af33ddcf1dd9ea359e8af6https://doi.org/10.3389/fmed.2025.1561886
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