August 19, 2025Scientific ReportsOpen Access

IGFBP3-mediated effects of an effective combination therapy on HCC

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Quercetin reduced cell viability and induced apoptosis in HCC cells, highlighting its therapeutic potential.
After treatment with quercetin, elevated levels of caspase-3 and caspase-9 were observed, confirming apoptosis induction.
RNA-seq analysis indicated IGFBP3 mediates quercetin's effects by reducing PI3K-mTOR activation.
Quercetin's combination therapy may offer a new approach for effectively treating HCC, with promising results in vivo.

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Observational analysis revealed quercetin's effects on apoptosis in HCC, indicating therapeutic potential through IGFBP3.

Chen et al. (2025) studied this question.

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