Terpenoid-derived β-ketoesters: ring expansion of camphor with diazoacetate and few transformations of homocamphor-3-carboxylate

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Synthesis of β-ketoesters from camphor using diazoacetate shows diastereoselective transformations, highlighting potential in organic synthesis.

The synthesis yielded both racemic and non-racemic homocamphor-based β-ketoester.
A key method was AlCl₃-catalyzed ring expansion of camphor, indicating a novel synthetic route.
Transformations included epimerization and functionalization of the β-ketoester, showcasing adaptability.
These findings may enhance the repertoire of methods available for synthesizing complex organic molecules.

Tkachenko et al. (2025) studied this question.

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Synthesis of β-ketoesters from camphor using diazoacetate shows diastereoselective transformations, highlighting potential in organic synthesis.