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August 19, 2025Clinical EndocrinologyOpen Access

Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome

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Authors

JFJiaxing FengRLRong LuoJCJing Cong

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Overview

Research shows that elevated ALT and AST relate to metabolic syndrome and insulin resistance in women with PCOS, suggesting specific enzyme reference ranges are needed.

Key Points

  • Increased aspartate aminotransferase and alanine aminotransferase levels are found in women with polycystic ovary syndrome.
  • Logistic regression analysis indicates a positive relationship between ALT, AST, and the prevalence of metabolic syndrome and insulin resistance.
  • Assessment using linear regression revealed significant correlations between liver enzymes and metabolic characteristics like body mass index and waist circumference.
  • Findings emphasize the importance of PCOS-specific enzyme reference ranges for diagnosing metabolic syndrome and insulin resistance.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68af33d5cf1dd9ea359e8766https://doi.org/10.1111/cen.70018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Aspartate Aminotransferase to Platelet Ratio Index Associated With Dyslipidaemia and Obesity in Patients With Polycystic Ovary Syndrome2025
  2. 2Association between AST/ALT ratio and the risk of gestational diabetes mellitus in Korean pregnant women2025
  3. 3Investigating the Relationship between Anthropometric Indices and Liver Enzymes in Employed Men and Women2025
  4. 4Impact of mean arterial pressure on reproductive endocrine characteristics in infertile patients with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial2025
  5. 5Evaluation of C-reactive protein/albumin ratio in women with polycystic ovarian syndrome and women without polycystic ovarian syndrome2025