August 19, 2025Frontiers in OncologyOpen Access

Case Report: Sequential PTCD and biliary seed stent combined with targeted-immunotherapy for advanced pancreatic cancer with malignant obstructive jaundice: a multidisciplinary approach

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Successful management of malignant obstructive jaundice led to a reduction in bilirubin levels from 116.9 to 45.6 μmol/L within a week.
Sequential therapy achieved a 78% reduction in CA19–9 levels, improving disease markers in a patient with advanced pancreatic cancer.
Emergency percutaneous transhepatic cholangial drainage was followed by biliary stenting and immunotherapy, demonstrating a multidisciplinary approach.
At the one-year follow-up, the patient reported a Karnofsky score of 90, indicating good quality of life post-treatment.

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Case report reveals effective intervention with PTCD and targeted-immunotherapy, improving outcomes in pancreatic cancer patients.

Li et al. (2025) studied this question.

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