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June 30, 2025Health of Man

Long-term Oncological Outcomes of Neoadjuvant Androgen-deprivation Therapy Prior to Radical Prostatectomy

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Authors

YAYevhenii AfanasievRDR.O. DanyletsVGV. Grygorenko

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Overview

Observational analysis improved biochemical recurrence-free survival in men with prostate cancer, indicating NADT enhances treatment effects alongside EBRT.

Key Points

  • NADT significantly improved biochemical recurrence-free survival, with a hazard ratio of 0.45.
  • Patients who received both NADT and external beam radiation therapy had the best overall and cancer-specific survival outcomes.
  • Analysis included 175 prostate cancer patients, evaluating their treatment response via Kaplan–Meier and Cox regression methods.
  • Long-term outcomes highlight the importance of treatment duration and intensity, especially for high-risk prostate cancer patients.

Cite This Study

Afanasiev et al. (2025) studied this question.

synapsesocial.com/papers/68af2ef6cf1dd9ea359e7347https://doi.org/10.30841/2786-7323.2.2025.337324
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