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August 18, 2025OncoImmunologyOpen Access

CyTOF profiling of bone marrow immune dynamics across myeloma stages

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Authors

DCDana CholujováGBGábor BekeĽKĽuboš Kľúčár

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Overview

Analysis shows immune remodeling in bone marrow of myeloma patients, indicating unique immune profiles linked to clinical outcomes.

Key Points

  • Substantial immune remodeling occurs during myeloma progression, leading to adaptive immune suppression and innate immune population changes.
  • Cohorts demonstrated specific alterations in T cell populations and myeloid lineages, with active myeloma linked to reduced transitional B cells.
  • CyTOF profiling provided insights into immune dynamics across myeloma stages, crucial for understanding pathogenesis and therapy response.
  • Identifying immune profiles associated with clinical outcomes can aid in developing prognostic biomarkers and personalized immunotherapies.

Cite This Study

Cholujová et al. (2025) studied this question.

synapsesocial.com/papers/68af2ef6cf1dd9ea359e7100https://doi.org/10.1080/2162402x.2025.2542333
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Also Consider

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  1. 1An immune proteomic atlas of 300 million bone marrow cells reveals prognostic cell states in multiple myeloma2025
  2. 2Mapping the cytotoxic landscape: an integrated analysis of T cell heterogeneity in the bone marrow microenvironment of multiple myeloma 28102025
  3. 3Highly multiplexed imaging recovers immune and metabolic niches in multiple myeloma associated with disease progression and bone involvement2025 · 1 citations
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  5. 5Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025