August 16, 2025NutrientsOpen Access

Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood–Cognitive Outcomes in Adults: A Structured Narrative Review

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Discussion

Narrative review shows vitamin D supplementation improves mood and cognitive outcomes in adults, indicating the role of BDNF.

Vitamin D supplementation improves mood and cognitive outcomes by modulating BDNF levels, especially in those with low vitamin D.
Supplementation of at least 2000 IU/day for 12 weeks decreased BDI scores by 1.7–7.6 points and increased BDNF by about 7%.
Observational analysis shows that each 10 ng/mL increase in vitamin D correlates with a 0.6-point rise in MMSE scores.
Vitamin D's potential benefits for mood and cognition highlight the need for further long-term studies to confirm findings.

Skoczek-Rubińska et al. (2025) studied this question.

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