August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Does Excitatory/Inhibitory Balance Predict Ketamine Response in Treatment-Resistant Depression? A Double-Blind Randomized Controlled Trial With 1h-MRS

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Higher baseline dACC Glx/GABA ratio predicted significant improvement in HDRS-17 scores after ketamine treatment, indicating a potential biomarker.
In ketamine group, reduction in Glx/GABA ratio correlated with enhanced improvement in depression scores, while placebo group showed no such association.
Double-blind randomized controlled trial evaluated ketamine's effects on individuals with treatment-resistant depression using proton magnetic resonance spectroscopy.
Findings suggest further research needed to validate E/I balance's role in treatment response for individuals with treatment-resistant depression.

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Implication

Randomized controlled trial determined ketamine's impact on depression in adults with treatment-resistant depression, suggesting E/I balance may aid prediction.

Cite This Study

Ohtani et al. (2025) studied this question.

synapsesocial.com/papers/68af2eeacf1dd9ea359e68ba https://doi.org/10.1093/ijnp/pyaf052.202

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Implication

Randomized controlled trial determined ketamine's impact on depression in adults with treatment-resistant depression, suggesting E/I balance may aid prediction.

Does Excitatory/Inhibitory Balance Predict Ketamine Response in Treatment-Resistant Depression? A Double-Blind Randomized Controlled Trial With 1h-MRS

Key Points

Discussion

Implication

Cite This Study

Does Excitatory/Inhibitory Balance Predict Ketamine Response in Treatment-Resistant Depression? A Double-Blind Randomized Controlled Trial With 1h-MRS

Key Points

Discussion

Implication

Cite This Study

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