Neuropsychiatric Symptoms as Predictors for Cognitive Impairment and Revert Factors for Normal Cognition: A One-Year Prospective Cohort Study

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Cohort study identifies neuropsychiatric symptoms' impact on cognitive decline and recovery, suggesting significant risk factors.

Over one year, 4.15% of participants with mild cognitive impairment progressed to dementia, while 33.16% reverted to normal cognition.
Multivariate analysis revealed that neuropsychiatric symptoms like delusions confer a 346 times greater risk of converting to dementia.
Assessment utilized the Neuropsychiatric Inventory Questionnaire across four intervals, tracking symptoms in older adults over time.
Findings underscore the importance of persistent neuropsychiatric symptoms as predictors of dementia risk and potential cognitive outcomes.

Thaipisuttikul et al. (2025) studied this question.

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