Targeting the Ventral Pallidum to Treat Opioid Use Disorder

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Opioid self-administration enhances the excitability of glutamatergic ventral pallidal neurons, potentially contributing to relapse.
Experiments showed that mu opioid agonists decrease the excitability of these neurons, highlighting their role in addiction.
Fluorescent in situ hybridization revealed mu opioid receptors are enriched in ventral pallidal glutamatergic neurons.
These findings suggest that altered neuron activity may drive negative reinforcement during opioid withdrawal.

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Investigating how opioid self-administration influences glutamatergic neuron function in decision-making related to opioid use disorder.

Mary R. Creed (2025) studied this question.

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