Association of Medication Use with the Development of Enamel Defects in Pregnancy and Childhood: A Critical Review of the Literature

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Critical review shows possible links between medication exposure and enamel defects in children, highlighting gaps in causal evidence.

Possible association between medication use and enamel defects in children, particularly with amoxicillin usage.
Of 1,362 studies reviewed, only 10 cohort studies were eligible, indicating a limited body of evidence in this area.
A systematic approach following PRISMA guidelines ensured a thorough examination of existing literature.
Further well-designed observational studies are needed to clarify the connection and inform pediatric dentistry practices.

Paulino et al. (2025) studied this question.

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View Full Paper

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Authors

Critical review shows possible links between medication exposure and enamel defects in children, highlighting gaps in causal evidence.

Possible association between medication use and enamel defects in children, particularly with amoxicillin usage.
Of 1,362 studies reviewed, only 10 cohort studies were eligible, indicating a limited body of evidence in this area.
A systematic approach following PRISMA guidelines ensured a thorough examination of existing literature.
Further well-designed observational studies are needed to clarify the connection and inform pediatric dentistry practices.

Paulino et al. (2025) studied this question.

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