August 18, 2025Open Access

Systemic Metabolic Rewiring in a Mouse Model of Left Ventricular Hypertrophy

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Observational analysis reveals metabolic changes in left ventricular hypertrophy, indicating exogenous LCFA may improve mitochondrial function.

Loss of the Mybpc3 gene led to significant decreases in adipose tissue and mitochondrial function, and heightened lipid accumulation in heart and liver.
Mice with left ventricular hypertrophy displayed altered metabolism, particularly a shift toward glucose utilization over fatty acid oxidation.
Supplementation of exogenous LCFAs enhanced mitochondrial function in heart and muscle, yet did not completely reverse hypertrophy or metabolic issues.
The findings suggest that left ventricular hypertrophy may lead to broader systemic metabolic shifts, impacting overall energy balance and health.

Schmidt et al. (2025) studied this question.

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Observational analysis reveals metabolic changes in left ventricular hypertrophy, indicating exogenous LCFA may improve mitochondrial function.