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August 18, 2025PLoS ONEOpen Access

Non-linear association between neutrophil-to-lymphocyte ratio and 90-day mortality in patients with pneumonia receiving glucocorticoids alone or in combination with other immunosuppressants: A retrospective cohort study

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Authors

CCCaizhen ChenXZXiuguo ZhangBLBaoli Li

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Implication

Retrospective cohort analysis shows non-linear association between neutrophil-to-lymphocyte ratio and 90-day mortality in pneumonia patients receiving glucocorticoids, highlighting its role as a biomarker.

Key Points

  • In pneumonia patients treated with glucocorticoids, a non-linear relationship exists between neutrophil-to-lymphocyte ratio and 90-day mortality.
  • The study found a 90-day mortality rate of 26.1% across 696 patients, with significant interaction effects for age and smoking status.
  • Cox hazard regression and ROC curve analyses were used to assess the association between NLR and 90-day mortality as well as establish the predictor's accuracy.
  • Findings suggest that NLR can serve as an effective biomarker for predicting mortality, with an optimal cutoff value identified at 16.475.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af2d89cf1dd9ea359e6140https://doi.org/10.1371/journal.pone.0329616
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