Potential of Alkaloids from Zanthoxylum nitidum var. tomentosum in Treating Rat Rheumatoid Arthritis Model and Validation of Molecular Mechanisms

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ARSHs significantly reduced joint inflammation and damage in CFA rats, pointing to their potent anti-inflammatory effects.
Therapeutic assessment included arthritis index, paw swelling, and serum cytokines, with p-values indicating strong efficacy in treatment.
Using a CFA-induced arthritis model in male SD rats, the study prioritized fifteen alkaloids and twenty-four targets for mechanistic analysis.
Results suggest that ARSHs function as multi-target phytotherapeutic agents, targeting critical signaling pathways involved in RA.

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Observational analysis shows alkaloids reduce inflammation in rheumatoid arthritis, highlighting the SRC/STAT3/MAPK3 signaling pathway.

Shen et al. (2025) studied this question.

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