August 18, 2025Open Access

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in mice with the common human variant in the μ-opioid receptor, Oprm1 A118G

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Distinct changes in cell dynamics were observed in opioid-exposed mice, revealing new insights into the Oprm1 variant's impact.
The research identified significant variations in glial cell adaptations rather than direct neuronal dysfunction linked to opioid dependence.
Analysis utilized spatial transcriptomics to provide a cross-modal understanding of gene expression in the context of addiction.
Findings emphasize the need for further exploration of neuroimmune interactions and their roles in opioid use disorder.

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Spatial transcriptomics reveals distinct cell type dynamics in opioid use disorder mice, highlighting the role of glial cells.

Blendy et al. (2025) studied this question.

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