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August 18, 2025PLoS ONEOpen Access

Declines and pronounced state-level variation in clozapine use among Medicare patients

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Authors

LCLuke R. CavanahMTMaria TianJGJessica L. Goldhirsh

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Overview

Analysis reveals a decrease in clozapine prescriptions for schizophrenia among Medicare patients, indicating underutilization issues.

Key Points

  • Clozapine use decreased by 18% among Medicare patients from 2015 to 2020, raising concerns about its underutilization.
  • There is significant state-level variation in clozapine prescriptions, with a nine-fold difference observed across the US.
  • Massachusetts and South Dakota demonstrated higher than average clozapine usage, while most states fell below the national average.
  • Interventions to improve clozapine use may include educational programs and reforms to facilitate blood monitoring.

Cite This Study

Cavanah et al. (2025) studied this question.

synapsesocial.com/papers/68af2d89cf1dd9ea359e5f93https://doi.org/10.1371/journal.pone.0328495
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A National Analysis of Facility-Level Clozapine Availability in U.S. Mental Health Services2025
  2. 2296. A POPULATION-BASED STUDY ON LONG-TERM MORTALITY RISK ASSOCIATED WITH CLOZAPINE USE AMONG PATIENTS WITH SCHIZOPHRENIA2025
  3. 3496. THE BENEFITS OF CLOZAPINE BEYOND ITS ANTIPSYCHOTIC PROPERTIES IN TREATMENT-RESISTANT SCHIZOPHRENIA2025
  4. 4Clozapine: prescribing practices in French psychiatric hospitals, multicenter survey on a given day2025
  5. 5Examining the Discontinuation of Clozapine Due to Serious Side Effects Over A Decade at a University Hospital Inpatient Clinic2025