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August 18, 2025DiabetesOpen Access

Diabetes Genetic Clusters and Clinical Outcomes in American Indians

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Authors

KRKaylia M. ReynoldsQSQuan SunYZYing Zhang

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Overview

Observational analysis reveals genetic factors linked to type 2 diabetes in American Indians, highlighting cardiometabolic implications.

Key Points

  • Total T2D polygenic score is significantly associated with early onset of type 2 diabetes; P = 3.5 × 10-11.
  • Genetic analysis of 3,084 American Indians shows an overlap in type 1 and type 2 diabetes genetic profiles.
  • Partitioned polygenic scores for T2D clusters relate to cardiometabolic traits, particularly in obesity and lipodystrophy cases.
  • Findings underscore the need for advanced clustering methods to leverage genetic variation in American Indian populations.

Cite This Study

Reynolds et al. (2025) studied this question.

synapsesocial.com/papers/68af2d89cf1dd9ea359e5f88https://doi.org/10.2337/db25-0322
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