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August 18, 2025Discover OncologyOpen Access

An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma

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Authors

HFHan FanPQPeng QiuYLYun Lu

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Overview

Analysis demonstrates a prognostic model using oxidative stress-related genes in cholangiocarcinoma, suggesting improved patient outcomes.

Key Points

  • The OSRG-based model effectively predicts patient survival in cholangiocarcinoma, differentiating between high and low risk groups.
  • Kaplan-Meier survival analysis indicated higher survival rates associated with high levels of RORA and GRIN2A expression.
  • This analysis utilized data from 66 cholangiocarcinoma tumors and 36 control samples, including differential gene expression.
  • The study highlights the relationship between immune cell infiltration and chemosensitivity in high-risk patients for targeted treatment.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68af2d83cf1dd9ea359e5e18https://doi.org/10.1007/s12672-025-03434-x
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