Retrospective analysis shows platelet count and volume relate to liver fibrosis severity and inflammation in NAFLD.
Key Points
Lower platelet count was associated with higher liver fibrosis stage and inflammation grade, indicating potential biomarkers for NAFLD-related complications.
The analysis revealed a strong negative correlation between platelet count and fibrosis stage (r = -0.640), suggesting lower counts may signal worsening liver health.
Independent risk factors for fibrosis progression included decreased platelet count and increased mean platelet volume/platelet distribution width.
Future prospective studies are needed to confirm the utility of these hematological indices as noninvasive biomarkers in managing NAFLD.