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July 25, 2025Open Access

Plants with promising antileishmanial activity in Colombia: a systematic review and meta-analysis

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Authors

CNCarlos Nieto‐ClavijoUniversidad El BosqueLMLiliana MoralesUniversidad El BosqueGZG. ZambranoUniversidad El Bosque

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Implication

Systematic review assesses antileishmanial activity of Colombian plants, indicating promising candidates with favorable selectivity indices.

Key Points

  • Colombian plants showed significant in vitro antileishmanial activity, linking specific extracts to higher potency.
  • The pooled mean IC 50 value was found to be 41.25 µg/mL, with heterogeneity observed across studies.
  • Systematic review and meta-analysis included 25 studies spanning 24 plant species, assessing various factors affecting efficacy.
  • The findings highlight the potential of Colombia's biodiversity in discovering novel antileishmanial therapies.

Cite This Study

Nieto‐Clavijo et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e59b4https://doi.org/10.1101/2025.07.20.665797
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