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August 16, 2025Molecular MedicineOpen Access

Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer

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Authors

BLBin LianJLJiayi LiSTShihui Tang

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Overview

In vitro and in vivo experiments demonstrate exosome-based siRNA delivery targeting LINC02544 enhances TNBC treatment, suggesting new therapeutic strategies.

Key Points

  • Exosome-mediated siRNA delivery targeting LINC02544 significantly reduced TNBC cell proliferation and migration, overcoming immune resistance.
  • In vitro, silencing LINC02544 upregulated miR-497-5p and downregulated CAPRIN1, impacting TNBC cell behavior.
  • LINC02544 was overexpressed in TNBC samples, indicating its potential as a diagnostic marker for this aggressive cancer subtype.
  • Combining exo/si-LINC02544 with a PD-1 inhibitor effectively suppressed tumor growth in a TNBC mouse model.

Cite This Study

Lian et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e5912https://doi.org/10.1186/s10020-025-01336-w
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