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August 16, 2025BMC MicrobiologyOpen Access

Butyrate enhances gut dysbiosis by activating the cAMP/PKA/CREB signaling pathway to inhibit the progression of endometrial carcinoma

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Authors

MTMuheng TaoTWTingting WuXZXin Zhou

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Overview

Investigation reveals butyrate affects gut microbiota and activates cAMP pathway, suggesting therapeutic potential in endometrial carcinoma.

Key Points

  • Butyrate supplementation significantly reduced the proliferation and migration of endometrial carcinoma cells, reversing gut dysbiosis.
  • RNA sequencing revealed activation of the cAMP/PKA/CREB signaling pathway associated with sodium butyrate treatment.
  • The gut microbiota composition showed significant alterations, including increased Proteobacteria in endometrial carcinoma patients.
  • Butyrate restored gut health and decreased inflammation markers in mouse models treated with fecal supernatants from patients.

Cite This Study

Tao et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e58a5https://doi.org/10.1186/s12866-025-04190-2
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