August 16, 2025Virology JournalOpen Access

Roles of inflammatory cytokines in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure and CAR-T therapy

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Lower IL-10 levels correlate with improved liver function in HBV-ACLF patients, showing clinical significance.
The IL-6/IL-10 ratio serves as a prognostic biomarker for both disease progression in HBV-ACLF and CAR-T therapy outcomes.
Study analyzed data from 68 HBV-ACLF patients and 372 CAR-T therapy recipients, indicating cytokine dynamics in liver failure.
Findings highlight the critical role of inflammatory cytokines in evaluating and managing HBV-ACLF and liver injury post-CAR-T.

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Implication

Retrospective cohort study links inflammatory cytokines to liver function in HBV-ACLF patients and CAR-T therapy recipients, suggesting prognostic biomarkers.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e57e3 https://doi.org/10.1186/s12985-025-02868-7

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Implication

Retrospective cohort study links inflammatory cytokines to liver function in HBV-ACLF patients and CAR-T therapy recipients, suggesting prognostic biomarkers.

Roles of inflammatory cytokines in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure and CAR-T therapy

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Discussion

Implication

Cite This Study

Roles of inflammatory cytokines in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure and CAR-T therapy

Key Points

Discussion

Implication

Cite This Study