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August 1, 2025Annals of Emergency MedicineOpen Access

Major Adverse Events with Chimeric Antigen Receptor T-Cell Therapy: Presentation, Diagnosis, and Resuscitation

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Authors

KDKiril DimitrovFMFlorian MerkleMDMarketa Dimitrov

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Overview

Clinical review highlights adverse events from chimeric antigen receptor T-cell therapy in patients, suggesting guidance for emergency physicians.

Key Points

  • Cytokine release syndrome and neurotoxicity are key adverse events associated with CAR-T therapy, requiring careful management in emergency settings.
  • Immune-related complications can mimic other serious conditions like sepsis, making timely diagnosis critical for patient care.
  • Emergency departments must recognize diverse symptoms of CAR-T toxicities, underscoring the need for targeted training and resources.
  • Limited guidance exists for managing CAR-T complications in both adult and pediatric patient populations, highlighting a crucial knowledge gap.

Cite This Study

Dimitrov et al. (2025) studied this question.

synapsesocial.com/papers/68af2d6fcf1dd9ea359e4fe7https://doi.org/10.1016/j.annemergmed.2025.07.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of cardiotoxicity with chimeric antigen receptor T-cell (CAR-T) therapy: A systematic review.2026
  2. 2OUT COMES AFTER CAR T CELL THERAPY IN THE LONG RUN2025
  3. 3Chimeric antigen receptor T cell therapy cardiotoxicity: a narrative review2026
  4. 4CAR-T cell Therapy; Toxicities and Current aspects of Management2025
  5. 5A Real‐World Study of CAR‐T Hematological Adverse Events Based on FAERS Database2025