This review examines antigen-presenting cells' interactions with African swine fever virus, highlighting implications for vaccine design.
Key Points
African swine fever virus disrupts antigen presentation pathways in immune cells, leading to potential vaccine-related challenges.
Current knowledge centers on monocyte/macrophage infection, but highlights the role of dendritic cells and other immune cells.
Systematic analysis of antiviral mechanisms reveals gaps in understanding host-pathogen interactions, impacting vaccine strategies significantly.
Addressing the interplay between antigen-presenting cells and ASFV could guide future vaccine development and improve countermeasures against outbreaks.