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August 1, 2025Stem Cell ReportsOpen Access

Germline transmission of cryopreserved mouse spermatogonial stem cells maintained on the International Space Station

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Authors

MKMito Kanatsu-ShinoharaTYTakuya YamamotoYSYusuke Shiromoto

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Overview

This research demonstrates the successful production of offspring from cryopreserved mouse spermatogonial stem cells, indicating potential for germline preservation in space exploration.

Key Points

  • Successful production of offspring was achieved from cryopreserved mouse spermatogonial stem cells stored in space.
  • Germline cells showed no increased apoptosis or DNA damage after six months on the International Space Station.
  • Spermatogonial transplantation and natural mating resulted in viable offspring, demonstrating the feasibility of SSCs in space research.
  • This research highlights the potential for gametogenesis preservation during long-duration space missions.

Cite This Study

Kanatsu-Shinohara et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4f4dhttps://doi.org/10.1016/j.stemcr.2025.102602
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